434.924.9333
Patient & Visitor Information

800.223.9173

Make an Appointment

434.924.9333

    

Cancer Center
Cancers We Treat

See All Cancers We Treat

Need a Second Opinion?

If you'd like to schedule an appointment for a second opinion, call 434.924.9333.

  

Need a Second Opinion?

If you'd like to schedule an appointment for a second opinion, call 434.924.9333.

Questions?

If you need to speak with someone about your appointment, call 434.924.9333.

  

Make an Appointment

If you'd like to make an appointment or get a second opinion, call 434.924.9333.

Google Search Cancer
Home > Cancers We Treat > Hematologic Cancer > Leukemia > Chronic Myelogenous Leukemia

Chronic Myelogenous Leukemia

Chronic Myelocytic Leukemia

Chronic myelogenous leukemia (CML) is a cancer of the blood and bone marrow. The bone marrow makes abnormal blood cells, including:

  • Myeloblasts
  • Red blood cells 
  • Platelets

CML progresses gradually. Over time, it may change into acute myelogenous leukemia (AML), a more aggressive type of leukemia. 

 

Causes

CML is almost always associated with a gene mutation in the Philadelphia chromosome. This mutation occurs during life. It is not passed from parent to child. In most cases, the cause of the mutation is not known. Studies show that exposure to large doses of radiation is associated with development of CML. It may be found in survivors of nuclear accidents or of atomic bomb blasts. However, most patients with the condition have not been exposed to radiation.

Symptoms of CML Leukemia

Possible symptoms include:

  • Tiredness
  • Lack of energy
  • Fatigue
  • Unexplained weight loss
  • Night sweats
  • Fever
  • Pain or a feeling of fullness below the ribs
  • Bone pain
  • Joint pain
  • Reduced exercise tolerance
  • Enlargement of the liver or spleen
  • Unexplained bleeding or unusual bruising

Diagnosis

Your doctor will examine your lymph nodes, liver and spleen for swelling. 

  • These tests will check your bodily fluids:
    • Blood tests
    • Bone marrow aspiration
    • Bone marrow biopsy
    • Routine microscopic exam
    • Bone, blood marrow, lymph node tissue or cerebrospinal fluid tests
    • Cytogenetic analysis
  • Your doctor may take pictures of your bodily structures with:
    • Chest X-ray
    • CT scan
    • MRI scan
    • Ultrasound

Treatments

Treatment options include:

  • Targeted drug therapy
  • Chemotherapy
  • High-dose chemotherapy with stem cell transplant
  • Donor lymphocyte infusion
  • Surgery

MAKE AN APPOINTMENT

Call 924.9333

 

Content was created using EBSCO’s Health Library. Edits to original content made by Rector and Visitors of the University of Virginia. This information is not a substitute for professional medical advice.

Stem Cell Transplant Program

Call us to schedule a consultation: 855.285.1122 or visit the program page for instructions on getting here and other important information.

Schedule an Appointment

Please call 855.285.1122 to schedule an appointment.