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Need a Second Opinion?

If you'd like to schedule an appointment for a second opinion, call 434.924.9333.

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Home > Clinical Trials & Research > Shared Resources > Metabolomics & Lipidomics Shared Resource

Metabolomics & Lipidomics Shared Resource

Metabolomics & Lipidomics Facility

The Cancer Center Shared Resource for Metabolomics & Lipidomics at the University of Virginia is an analytical facility specializing in mass spectrometry techniques for assessing small molecules. These approaches encompass a variety of targeted, untargeted, qualitative, and quantitative analyses to support investigators in their research. The core has experience with a variety of sample types, including mammalian (cells, tissues, fluids), plants, insects, and biomaterials. Example analyses include the following:

Untargeted metabolite/lipid analyses

Generally a hypothesis generating experiment, these approaches will profile changes in metabolites between groups.

Targeted metabolite/lipid analyses

Various methods are available for targeted analyses of metabolites to determine steady-state levels. These include amino acids, organic acids, short-chain fatty acids, eicosanoids, acyl-CoAs, acyl-carnitines, sphingolipids, and more. Assays can be developed for your compound(s) of interest.

Metabolic Flux

Flux analyses serve to test mechanisms for altered steady-state levels of metabolites. Stable isotope labeled compounds (e.g. 13C, 2H and/or 15N) are used to assess the activity through a pathway.

Drug Metabolism and Pharmacokinetics

The Core can aid in determining various in vitro and in vivo properties of drugs. Examples include, microsomal stability, half-life, protein binding, and determination of phase I and II metabolites.

Mass spectrometry has applicability beyond the above listed categories. We are open to applying new approaches and developing new methods to aid investigators in their research needs.

 

Contact Us:

Please contact Dr. Todd Fox to discuss projects.

Submit a project request in iLab at https://uva.corefacilities.org/service_center/show_external/4075