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Home > Clinical Trials & Research > Shared Resources > MAPS > MAPS Core Facility Services

MAPS Core Facility Services

Preclinical Studies

Consultation

To ensure the highest probability that an experiment will be fully informative, we offer consultation from our experienced staff and board of technical and scientific experts in the design of animal experiments from start to finish. Areas of consideration include cost estimations; animal welfare committee (IACUC) and biosafety committee (BSL) regulatory compliance; logistical detailing and planning; biostatistics; specimen collection, storage and analysis; imaging and molecular assessments. Please note: necessary regulatory approvals to perform the studies must be obtained before studies can ensue.

*Billed in 30 minute increments at $90/hour

Project Management

The profile of animal research studies can range from short and uncomplicated to intricate, time-consuming and lengthy. The MAPS Core has the dedicated staff and expertise to initiate your study and perform it to completion, however complicated or simple. Additionally we can coordinate any necessary services in other UVA Shared Resources facilities for you, thereby providing a single point of contact for a PI to carry out an entire study that might include the culture of cells, immunohistochemistry, flow cytometry, molecular analyses of tumors, and statistics.

*Billed in 30 minute increments at $90/hour

Therapeutic Dosing

We prepare and administer single and combination therapeutics in treatment regimens as well as maximum tolerated dose evaluations. Therapeutics includes Small Molecules, Biopharmaceuticals, Vaccines, Radio-sensitizers, Medical Devices, and Nanotechnology Therapies.

Gavage, IP, SC - $1.5 per dose
Hormone Pellet Implants - $10
IV - $6.25 per dose
Pumps Osmotic/Infusion Pump Implantation - $35
Pumps Osmotic/Infusion Pump Priming and Implantation - $50
Medicated Feed & Water – $7.50/cage

*Supplies not included in pricing

Animal Monitoring

We offer once and twice weekly animal monitoring in the forms of animal weight checks, health assessments, tumor measurements, imaging services, pain assessment, blood sampling, etc.

Animal Identification - $1.50/mouse
Caliper Measurements, Health Monitoring & Weights - $11.25 for unilateral, $14.50 bilateral/ box, includes data entry
Imaging services - $90/hour, luciferin extra
Staple Removal - $1.50/mouse
Three day post-operative monitoring - $67.50/cage
Weights only - $7.50/box, includes data entry

Cancer Xenografts

Subcutaneous Model is the placement of cells and tumor pieces just beneath the skin on the flank or hind leg. This is the common xenograft model for patient tumor propagation, simple tumor growth analysis, chemotherapeutic dose response analysis as well as some radiation studies.

Cell Injections – $5 each
Tumor Propagations SC - $15 each, $20 bilateral

*Supplies not included in pricing any animal prep, i.e. depilation, also not included

Orthotopic Model is the deposit of cells or tumor pieces in the anatomical location of cancer origin including renal capsule, spleen capsule, ovarian bursa, intra-tracheal, pancreas, intra-peritoneal, intra-vesicular/bladder, inter-coastal to the lungs, mammary fat pad, prostate, tibia and femur. This approach aims to mimic the tissue environment of a primary tumor more accurately than subcutaneous implantation.

Bladder - $65
Cheek -
Colon - $35
Femur - $35
Kidney - $35
Mammary gland – $5
Ovarian Bursa - $35
Pancreas - $35
Peritoneal - $5 cell, $35 tumor
Prostate - $35
Tongue - $15

*Supplies and any animal recovery time not included in pricing

Metastases Model is the occurrence of transplantable metastases from syngenic models, orthotopic xenograft models, tail vein, and intra-cardiac injections of cells.

Carotid - $35
Intra-cardiac - $25
Intravenous - $6.25

*Supplies and any animal recovery time not included in pricing

Specimen Collection

Blood/Serum Harvest - $22.50
Tumor Harvest – includes necropsy, tumor removal, photographs and reporting

Surgical Services

We offer cardiovascular, castrations, catheterizations, oophrectomies, thyroidectomies, and many others as needed to develop the correct animal model for specific studies.

*Supplies and any animal recovery time not included in pricing

Training

Our staff can advise and train investigators to perform and manage some or all parts of their studies themselves.

*Billed on an hourly basis at $90/hour to the half hour

 

Please contact Core Director or faculty director   for further details or to discuss a project.